The Science Behind

Chillstrip

Grounded in Nobel Prize research and clinical expertise.

Nobel Prize Foundation

Chillstrip’s development is inspired by groundbreaking Nobel Prize research on menthol’s unique ability to mimic cooling effects at the molecular level. This research revealed how menthol activates TRPM8 cold receptors, providing therapeutic benefits that go beyond simple temperature sensation.

Our team leveraged these findings to create a precise delivery system that optimizes menthol’s therapeutic properties for TMJ relief, ensuring maximum efficacy with minimal side effects.

Key Research Insights

  • TRPM8 receptor activation reduces pain perception
  • Controlled cooling effects promote muscle relaxation
  • Localized therapy minimizes systemic side effects 
  • Sustained release provides overnight relief

Therapeutic Mechanisms

Cooling Phase

Initial menthol activation provides immediate cooling sensation, reducing inflammation and acute discomfort

Warming Transition

Gentle warming phase promotes vasodilation and muscle relaxation, improving blood flow to affected areas.

Sustained Relief

Controlled release technology maintains therapeutic levels throughout the night for consistent comfort.

Clinical Validation

Chillstrip has undergone rigorous testing to validate its safety and efficacy. Clinical studies demonstrate significant improvements in patient-reported outcomes for TMJ-related discomfort.

  • FDA-compliant materials and testing
  • Biocompatibility verification
  • Patient safety monitoring

Ongoing Research

At KironLabs, we continue to advance the science of TMJ therapy through ongoing research and development initiatives.

  • Next-generation delivery systems
  • Personalized therapy protocols
  • Combination therapy optimization
TRPM8
Credit: Sergii Palchevskyi, Mariusz Czarnocki-Cieciura, Giulio Vistoli, Silvia Gervasoni, Elżbieta Nowak, Andrea R. Beccari, Marcin Nowotny & Carmine Talarico

Experience Science -Backed Relief

Discover how decades of research translate into real therapeutic benefits.

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